Multivariate Curve Resolution: 50 years addressing the mixture analysis problem – A review

Non-linear multivariate curve resolution analysis of voltammetric pH titrations.

A new chemometric approach is put forward, dealing with the non-linear behaviour observed in the multivariate curve resolution (MCR) analysis of certain overlapping voltammetric signals obtained in titrations of metal complexes where pH is progressively changed. In such cases, non-reversible reduction signals move along the potential axis as a consequence of the involvement of H(+)-ions in the ...

Screening for a Multivariate Mixture Normal Distribution

A study of the photo-degradation kinetics of nifedipine by multivariate curve resolution analysis.

A multivariate curve resolution method based on the combination of Kubista approach and iterative target transformation method of Gemperline has been proposed. This method is a soft model and need no information about the spectrum of the product and mechanism of the reaction. The method was used to study the degradation kinetics of nifedipin, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyrid...

Multivariate curve resolution: a powerful tool for the analysis of conformational transitions in nucleic acids.

A successful application is reported of the multivariate curve resolution alternating least-squares method (MCR-ALS) for the analysis of nucleic acid melting and salt-induced transitions. Under conditions where several structures co-exist in a conformational equilibrium, MCR-ALS analysis of the UV and circular dichroism (CD) spectra at different temperatures, ionic strength and oligonucleotide ...

Potential use of multivariate curve resolution for the analysis of mass spectrometry images.

In this work the application of multivariate curve resolution is proposed for the analysis of Mass Spectrometry Imaging (MSI) data. Recently, developments in the ionization of samples have dramatically expanded the number of applications of MSI due to the possibility of collecting the mass spectrum for each pixel of a considered surface in a reasonable time. Using this method, both spatial dist...